Tim Paine and John Hastings will undertake surgeries and have been lined out of Australia's short-format teams for next month's tour of South Africa.
The duo both need surgery on injury which will rule them out of the two Twenty20 and three one-day internationals, which get beneath way with the opening T20 clash in Cape Town on October 13.
Wicketkeeper-batsman Paine has been stressed with a long-term finger injury and Australia team physiotherapist Alex Kountouris said: "Tim Paine wounded his right index finger batting at training with his Tasmanian state team four weeks ago. He sustained a fracture in a similar part of the same finger late last year and necessary surgery.
"Tim has been inactive the injury in recent weeks but is still experience considerable pain. His surgeon has advised that the fracture is healing slower than predictable and may not heal without surgical interference. As such, Tim will be undergoing surgery later this week.
"He is likely to need a comprehensive recuperation period following surgery and will not be available for collection for the T20 and ODI tour of South Africa."
All-rounder Hastings picked up a shoulder injury with his state side after frequent from Australia's tour of Sri Lanka and has been lined out for an undetermined period.
"He has had ongoing shoulder pain since this event and has been not capable to return to training," Kountouris explain.
"He has consulted a surgeon who has recommended surgery. It is likely that he will have surgery sometime in the next week after further assessment from the surgeon.
"His return to cricket will be needy on the management approach pursued."